کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4932894 | 1433535 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 49, January 2017, Pages 218.e13-218.e15
Journal: Neurobiology of Aging - Volume 49, January 2017, Pages 218.e13-218.e15
نویسندگان
Ziv Gan-Or, Jacques Y. Montplaisir, Jay P. Ross, Judes Poirier, Simon C. Warby, Isabelle Arnulf, Stephanie Strong, Yves Dauvilliers, Claire S. Leblond, Michele T.M. Hu, Birgit Högl, Ambra Stefani, Christelle Charley Monaca, Valérie Cochen De Cock,