Euglena-based neurocomputing with two-dimensional optical feedback on swimming cells in micro-aquariums

► Nurocomputing with Euglena cells in micro-aquariums with 2D optical feedback. ► Dynamic transition among best solutions in 4-city TSP combinatorial optimization. ► Spontaneous fluctuation and photophobic reactions of Euglena cells. ► Similar behaviors as Boltzmann machine with stimulated annealing. ► Deadlock avoidance or program-less adaptation based on Euglena survival strategies.