Graph-based Framework for 3-D Vascular Dynamics Simulation

Vascular network dynamics has crucial impact on vertebrate physiology and numerous diseases are indicated by its malfunctioning. As a consequence, there is a high demand for tools facilitating the studies of the associated phenomena. However, many of them are focused strictly on the 2-D environments, similar to the ones used by in vitro research. Hence, they are rather useless for tumour development or drug interactions modelling purposes, as those processes need to be investigated in a 3-D setup. We address this issue by proposing a novel framework that allows to simulate vasculature growth and restructuration in 3 dimensions. Our solution yields morphologically accurate results, exhibiting properties found in real-world data, such as vein-artery interdigitation. Its graph-based architecture streamlines the outcome analysis and enables a straightforward way of including additional workflow extensions.