کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4973521 1451648 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insulin sensitivity and sepsis score: A correlation between model-based metric and sepsis scoring system in critically ill patients
ترجمه فارسی عنوان
حساسیت به انسولین و نمره سپسیس: همبستگی بین نمره دهی مبتنی بر مدل و سیستم نمره دهی در بیماران مبتلا به بحرانی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر پردازش سیگنال
چکیده انگلیسی
Sepsis is highly correlated with mortality and morbidity. Sepsis is a clinical condition demarcated as the existence of infection and systemic inflammatory response syndrome, SIRS. Confirmation of infection requires a blood culture test, which requires incubation, and thus results take at least 48 h for a syndrome that requires early direct treatment. Since sepsis has a strong inflammatory component, it is hypothesized that metabolic markers affected by inflammation, such as insulin sensitivity, might provide a metric for more rapid, real-time diagnosis. This study uses clinical data from 30 sepsis patients (7624 h in ICU) of whom 60% are male. Median age and median Apache II score are 63 years and 19, respectively. Model-identified insulin sensitivity (SI) profiles were obtained for each patient, and insulin sensitivity and its hourly changes were correlated with modified hourly sepsis scores (SSH1). SI profiles and values were similar across the cohort. The sepsis score is highly variable and changes rapidly. The modified hourly sepsis score, SSH1, shows a better relation with insulin sensitivity due to less fluctuation in the SIRS element. Median SI and median ΔSI of the cohort is 0.4193e-3 and 0.004253e-3 L/mU.min, respectively. Additionally, median SI are 4.392 × 10−4 L/mU min (SSH1 = 0), 4.153 × 10−4 L/mU min (SSH1 = 1), 3.752 × 10−4 L/mU min (SSH1 = 2) and 2.353 × 10−4 L/mU min (SSH1 = 3). Significant relationship between insulin sensitivity across different SSH1 groups was observed (p < 0.05) even when corrected for multiple comparisons. CDF of SI indicates that insulin sensitivity is more significant when comparing an hourly sepsis score at a very distinguished level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedical Signal Processing and Control - Volume 32, February 2017, Pages 112-123
نویسندگان
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