Nanostructuring Biomaterials with Specific Activities towards Digestive Enzymes for Controlled Gastrointestinal Absorption of Lipophilic Bioactive Molecules

• Lipase-mediated digestion controls the rate of lipophilic drug solubilisation.
• The mechanism of lipase action is a complex, interfacial phenomena.
• The interfacial composition of lipid alters the lipase:lipid interaction.
• Engineering colloids with specific material characteristics can modulate lipolysis.
• Insights provide new approaches for designing lipid-based delivery systems.