کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5008880 | 1462040 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An iridium(III) complex-based chemosensor for the detection of thiourea in living cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
The adverse effects that thiourea can induce in biological systems demand the development of new methods for its detection. In this work, we present a iridium(III) complex-based chemosensor (1) containing a recognition unit for thiourea. The reaction of the recognition unit with thiourea affects the long-lived excited states of the complex, leading to an enhancement of luminescence. Complex 1 showed a 3.3-fold enhanced luminescence in the presence of thiorea and a good linear relationship with thiourea ranging from 10 to 200 μM, with a limit of detection (LOD) of 3.85 μM. By using time-resolved emission spectroscopy (TRES), complex 1 could detect thiourea in the presence of interfering fluorescence. Moreover, complex 1 offers the capability to image thiourea in living HeLa cells. To our knowledge, complex 1 is the first iridium(III) complex-based sensor reported for imaging thiourea in living cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 251, November 2017, Pages 374-379
Journal: Sensors and Actuators B: Chemical - Volume 251, November 2017, Pages 374-379
نویسندگان
Wanhe Wang, Zhen-Zhen Dong, Chao Yang, Guodong Li, Yam-Chi Tse, Chung-Hang Leung, Dik-Lung Ma,