Pillararene-based fluorescent indicator displacement assay for the selective recognition of ATP

- The supramolecular analytical potential of water soluble pillararenes was further examined.
- The complexation of Dapoxyl sodium sulfonate was investigated with ammonium pillar[6]arene.
- The recognition of ATP was exploited in the first indicator displacement system for nucleotides based on a pillararene.
- An order of magnitude of selectivity over ADP and GTP was achieved in this model system.

The complexation of the cationic, water soluble ammonium pillar[6]arene was investigated with Dapoxyl sodium sulfonate. Large fluorescence enhancement was observed upon partial inclusion and the resulting complex was used as the first pillararene-based indicator displacement system for the selective recognition of adenosine-5′-triphosphate.

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