A novel coumarin based molecular switch for the sequential detection of Al3+ and F−: Application in lung cancer live cell imaging and construction of logic gate

- Development of novel coumarin based molecular switch for sequential detection of Al3+ and F−.
- UV-Vis and emission spectral changes confirms the sensing property of the developed chemosensor H2L.
- DFT used to get insight into the sensing mechanism and electronic structure of the chemosensor H2L.
- H2L is efficient in detecting Al3+ in the intracellular region of human lung cancer cell line A549.
- Exhibits an INHIBIT logic gate with Al3+ and F− as chemical inputs by monitoring the emission mode at 610 nm.

A highly sensitive and selective coumarin based chemosensor H2L for the efficient detection of Al3+ has been developed. The synthesized chemosensor H2L is efficient in detecting Al3+ over other metal ions which are commonly obtained in various physiological and environmental samples. H2L shows fluorescence 'turn-on' response at 610 nm in presence of Al3+, without the interference of other metal ions. The resulting H2L-Al3+ complex behave as a sequential chemosensor for F−, by showing quenching of emission intensity upon addition of F− to it. This quenching of emission intensity is only specific for F− and is not hampered due to the presence of other anions that commonly coexist with F− in various environmental solutions. Theoretical calculations using DFT/B3LYP method has been used to get insight into the sensing mechanism as well as electronic structure of the synthesized chemosensor H2L. H2L is efficient in detecting Al3+ in the intracellular region of human A549 cell and also exhibits an INHIBIT logic gate with Al3+ and F− as chemical inputs by monitoring the emission mode at 610 nm.

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