Neurodynamic correlates of response inhibition from emerging to mid adulthood

- We investigated response inhibition throughout young adulthood.
- Using a visual Go/No-Go task, we found age differences in performance and ERPs.
- Younger groups showed impulsive performance tendencies, delayed N2 and reduced P2 and P3.
- Refinement of motor inhibitory network is still ongoing in early 20s.

Response inhibition, a key executive function, continues to develop in early adulthood in parallel with maturational processes of the underlying prefrontal regions known to support it. The current study examined behavioral and neurophysiological correlates of response inhibition during a visual Go/No-Go task in a large sample (N = 120) comprised of participants in their Early 20s (ages 19-21), Mid 20s (ages 23-27), and Early 30s (ages 28-42). The two younger groups had lower accuracy, shorter reaction times, and made more premature responses compared to Early 30s. These impulsive behavioral tendencies were reflected in a delayed N2 latency and reduced P2 and P3 amplitudes for Early 20s compared to Early 30s and were associated with personality traits such as impulsivity in an age-dependent manner. The results suggest that response inhibition may not develop fully before the approximate age of 25, as the refinement of the primarily prefrontal cognitive control network follows a protracted developmental trajectory throughout young adulthood.