کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
504447 864305 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo reflectance-mode confocal microscopy provides insights in human skin microcirculation and histomorphology
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
In vivo reflectance-mode confocal microscopy provides insights in human skin microcirculation and histomorphology
چکیده انگلیسی

PurposeVarious approaches are used to study microcirculation, however, no modality evaluates microcirculation and histomorphology on cellular levels. We hypothesized that reflectance-mode confocal microscopy (RCM) enables simultaneous evaluation in vivo of both microcirculation and histomorphology.PrincipalsThe forearm of 20 volunteers was exposed to either local heat stress (HS-group), or to local cold stress (CS-group). RCM was performed prior and after temperature stress to evaluate quantitative blood-cell flow, capillary loop diameter, granular cell size, and basal layer thickness.ResultsIn the HS-group, we observed significant increase in capillary loop diameter and increased blood-cell flow after heat stress. In the CS-group, significant decreases of capillary loop diameter and in blood-cell flow were determined following cold stress. Granular cell size and basal layer thickness differed insignificantly prior and after local temperature stress.ConclusionsRCM provides real-time and in vivo high resolution imaging of temperature-dependent changes in the human skin microcirculation and histomorphology on cellular levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computerized Medical Imaging and Graphics - Volume 33, Issue 7, October 2009, Pages 532–536
نویسندگان
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