کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
505584 | 864521 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of the characteristics of oral dosage forms with release controlled by erosion
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
نرم افزارهای علوم کامپیوتر
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چکیده انگلیسی
This paper is concerned with oral dosage forms with controlled release based on the erosion of the polymer matrix. A numerical model taking all the facts into account, i.e., the kinetics of release and pharmacokinetic parameters of the drug, makes it possible to calculate the plasma drug level. Diagrams are built which connect the half life times obtained either through i.v. or with these dosage forms as a function of the full time of erosion of the polymer. Thus, it is possible to determine the right dosage form matrix associated with the desired therapy. Their interest stands for possible bioadhesion extending the gastrointestinal tract time.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 38, Issue 6, June 2008, Pages 668–675
Journal: Computers in Biology and Medicine - Volume 38, Issue 6, June 2008, Pages 668–675
نویسندگان
Iosif-Daniel Rosca, Jean-Maurice Vergnaud,