کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
505804 864539 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Algorithm for perturbing thermodynamically infeasible metabolic networks
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
Algorithm for perturbing thermodynamically infeasible metabolic networks
چکیده انگلیسی

Networks of reactions inside the cell are constrained by the laws of mass and energy balance. The second law of thermodynamics further constrains the topology of the metabolic network, by disallowing interactions that can sustain themselves when they are isolated from the rest of the network. We present an algorithm that identifies such subnetworks and makes them feasible by deleting reactions. This perturbs the network topology, but preserves the optimality of the mass balance solutions. This method has been applied to a full network of Escherichia coli.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 37, Issue 2, February 2007, Pages 126–133
نویسندگان
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