Review of analytical methodologies for the determination of 5-HT3 receptor antagonists

Serotonin 5-hydroxytryptamine (5-HT3) receptor antagonists (setron derivatives) are drugs used to treat patients with chemotherapy-induced or postoperative nausea and vomiting. The first-generation of 5-HT3 receptor antagonists are ondansetron, dolasetron, granisetron, and tropisetron and the second-generation is palonosetron. The aim of this work is to review the analytical methods used to determine these drugs from 1990 to 2016.