کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5142026 1496020 2017 28 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of invitro α-amylase and α-glucosidase inhibitory potential of N2O2 schiff base Zn complex
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Evaluation of invitro α-amylase and α-glucosidase inhibitory potential of N2O2 schiff base Zn complex
چکیده انگلیسی
The evaluation of the antioxidant, antibacterial and enzyme inhibition effects of N2O2 Schiff base Zn complex was investigated. The percentage scavenging activity of hydroxyl radical (IC50-0.21 μg), ABTS (IC50-0.19 μg) and DPPH (IC50-0.25 μg) shows that ZnL complex had a potential antioxidant activity. The antibacterial activity of ZnL complex was evaluated. Results showed that MIC value against Staphylococcus aureus and Salmonella typhi was 100 and 200 μg/ml, respectively. ZnL complex showed strong inhibition toward α-amylase and α-glucosidase with an IC50 value of 0.18 and 0.23 μg, respectively. The inhibition mechanism was analyzed with LB and Dixon plots. The ZnL complex could be a mixed noncompetitive and noncompetitive inhibitor with Ki values of 77.8 and 31.6 μg for α-amylase and α-glucosidase, respectively. The preliminary assessment of ZnL complex showed that they can be used as an antioxidant, antibacterial and antidiabetic agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 10, Issue 5, July 2017, Pages 732-738
نویسندگان
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