کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142028 | 1496020 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel synthesis of biologically active indolo [3,2-C] isoquinoline derivatives
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Indole-2-carboxylates are refluxed with hydrazine hydrate to form 5-substituted-3-phenylindole-2-carboxyhydrazides. These are again converted to corresponding indole-2-carboxyazides. Azides are further converted into carbamates and finally these carbamates are cyclized to form the respective substituted 6H, 11H-indolo [3,2-C] isoquinolin-2-ones (1a-c). These (1a-c) were reacted with phosphorus pentasulfide in refluxing pyridine to yield the respective thiones (2a-c). These thiones (2a-c) on reaction with chloroacetic acid and sodium acetate in acetic acid under refluxing temperature for 5Â h yielded isoquinoline-thioacetic acids (3a-c). Compounds (3a-c) on reaction with orthopheneylene diamine dihydrochloride in ethylene glycol at refluxing temperature yielded substituted indolo [3,2-C] isoquinolin-2â²-yl sulfanyl methylene benzimidazoles (4a-c).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 10, Issue 5, July 2017, Pages 746-749
Journal: Arabian Journal of Chemistry - Volume 10, Issue 5, July 2017, Pages 746-749
نویسندگان
Prabhuodeyara M. Veeresha Sharma,