A novel four-component route to synthesis 11-amino-12-(4-aryl)-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ol derivatives

A series of chromeno[2,3-b]quinolinol derivatives were synthesized through one-pot four-component reaction of resorcinol, malononitrile, aromatic aldehydes and cyclohexanone using iron(III) triflate Fe(OTf)3, under solvent-free and ultrasonic irradiation conditions. The products were afforded in good to excellent yields. The advantages of this method are the use of an inexpensive and readily available catalyst, short reaction time, easy workup and improved yields.