Synthesis, spectral characterization and biological activity of Zn(II) complex with 2′-[1-(2-hydroxyphenyl)ethylidene]benzenesulfanohydrazide

► Carried out toxicological evaluation in various animals to select safe dose in humans. ► Used cimetidine as standard antiulcer drug as it can decrease the acid output. ► Indicated that benzenesulfanohydrazones of Zn(II) complex is similar to histamine H2. ► Found that Zn(II) benzenesulfanohydrazone complex is reduced gastric lesions. ► Concluded that inhibition activity of Zn(II)benzenesulfanohydrazide complex was higher.