کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142361 | 1496025 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TiCl4: An efficient catalyst for one-pot synthesis of 1,2-dihydro-1-aryl-naphtho-[1,2-e][1,3]oxazin-3-one derivatives and their drug score analysis
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Multi-component, economical and efficient synthesis of 1,2-dihydro-1-aryl-naphtho[1,2-e][1,3]-oxazin-3-one derivatives (4a-k) with an excellent yield is described through a one-pot condensation of β-naphthol, aromatic aldehydes and urea in presence of catalytic amount of TiCl4 (10 mol%) under conventional heating and microwave irradiation. The role of catalyst in the conversion of reactants to the final compounds is described. All the compounds have been characterized by spectral (IR, 1H, 13C NMR and Mass) and analytical data. The pharmacological parameters of title compounds were also analyzed for their bioavailability by Osiris property explorer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 10, Supplement 2, May 2017, Pages S1760-S1764
Journal: Arabian Journal of Chemistry - Volume 10, Supplement 2, May 2017, Pages S1760-S1764
نویسندگان
Raveendra Hunnur, Ravindra Kamble, Atukuri Dorababu, B. Sunil Kumar, Chinna Bathula,