کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142388 | 1496025 | 2017 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, antimicrobial, anticancer evaluation and QSAR studies of Nâ²-substituted benzylidene/2-hydroxynaphthalen-1-ylmethylene/3-phenylallylidene/5-oxopentylidene -4-(2-oxo-2-(4H-1,2,4-triazol-4-yl) methylamino)benzohydrazides
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A series of 1,2,4-triazole derivatives (1-17) was synthesized and evaluated for its antimicrobial and anticancer potentials. Antimicrobial screening of the synthesized compounds indicated that they were most potent against Aspergillus niger and compound 14 was found to be the most active. Compound 7 showed appreciable anticancer activity against HCT 116, a colon cancer cell line. QSAR analysis indicated the importance of topological parameter, valence third order molecular connectivity index (3Ïv) and electronic parameter, dipole moment (μ) in describing the antimicrobial activity of the synthesized compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 10, Supplement 2, May 2017, Pages S2009-S2017
Journal: Arabian Journal of Chemistry - Volume 10, Supplement 2, May 2017, Pages S2009-S2017
نویسندگان
Sumit Tahlan, Pradeep Kumar, Kalavathy Ramasamy, Vasudevan Mani, Rakesh Kumar Mishra, Abu Bakar Abdul Majeed, Balasubramanian Narasimhan,