Synthesis and evaluation of antipsychotic activity of 11-(4′-(N-aryl carboxamido/N-aryl-α-phenyl-acetamido)-piperazinyl)-dibenz[b,f][1,4]-oxazepine derivatives

In the present study, a series of new substituted N-11-(4′-N-aryl carboxamido/N-(aryl)-α-phenyl-acetamido-piperazinyl)-dibenz[b,f][1,4]-oxazepine derivatives were designed on a revised structural model, length and nature of linker and introduced aryl group. All the compounds (MJ1-MJ12) were synthesized by economical route and confirmed by IR, 1H NMR, and mass spectral analyses. The antipsychotic potentialities of the synthesized derivatives were evaluated in mice by catalepsy and foot sock induced aggression. The present study demonstrates significant antipsychotic activity for most of the compounds from series. Compounds MJ-1, MJ-3 and MJ-4 were found to be potent antipsychotic compounds of the series at 5 mg/kg dose level when compared with the reference drug clozapine.