Conventional and microwave techniques for the synthesis and antimicrobial studies of novel 1-[2-(2-chloro-6-methyl(3-quinolyl))-5-(4-nitrophenyl)-(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones

In this paper, we have described the conventional and microwave methods for the synthesis of 1-[2-(2-chloro-6-methyl(3-quinolyl))-5-(4-nitrophenyl)(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones (4a-l). Through this method, we have observed a decrease in reaction time and a better yield than the previously described conventional method. The application of microwave irradiation (MWI) is used for carrying out chemical transformations which were pollution free and eco-friendly. The structures of the compounds were characterized by IR, NMR and mass spectral data. These compounds (4a-l) were evaluated for their in vitro antimicrobial screening on different strains of bacteria and fungi. Among the compounds tested, compound 4h showed the highest activity.