کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142507 | 1496034 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antihyperlipidemic activity of some novel 4-substituted-2-substitutedmethyltriazino[6,1-b]quinazolin-10-ones and 2,4-disubstituted-6,7-dimethoxy quinazoline
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antihyperlipidemic activity of some novel 4-substituted-2-substitutedmethyltriazino[6,1-b]quinazolin-10-ones and 2,4-disubstituted-6,7-dimethoxy quinazoline Synthesis and antihyperlipidemic activity of some novel 4-substituted-2-substitutedmethyltriazino[6,1-b]quinazolin-10-ones and 2,4-disubstituted-6,7-dimethoxy quinazoline](/preview/png/5142507.png)
چکیده انگلیسی
The synthesis and antihyperlipidemic activity of some novel 4-substituted-2-substitutedmethyltriazino[6,1-b]quinazolin-10-ones and 2,4-disubstituted-6,7-dimethoxy quinazoline derivatives are described. Among the series 4-chloro-2-acetoxymethyl-3H,11H-[1,2,4]triazino[6,1-b] quinazoline-4,10-dione 5d has shown better activity in case of % reduction in serum cholesterol level while 4-chloro-10-oxo-10H-[1,2,4]triazino[6,1-b]quinazolin-2-yl benzoate 5f in reducing % serum triglyceride level than that of the standard. 4-Hydroxyquinazolin-2-yl nicotinate 6g has significantly increased serum HDL level. Among the series compound 6g has shown promising results over all in lipid profile. These molecules indeed have the potential to be developed as an antihyperlipaemic molecule.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S395-S403
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S395-S403
نویسندگان
M.K. Kathiravan, Nikhil Vidyasagar, Rahul Khiste, Aparna Chote, Kishor Jain,