کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5142541 1496034 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives
ترجمه فارسی عنوان
سنتز، خصوصیات و فعالیت ضد مالاریا مشتقات 4-آمینو کینولین-1،3،5-تریازین ترکیبی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی
A novel series of hybrid 4-aminoquinolines-1,3,5-triazine were synthesized by means of aromatic nucleophilic displacement of chlorine atoms of 2,4,6-trichloro-1,3,5-triazine. Afforded title analogs were subsequently characterised by elemental analysis, FT-IR, 1H NMR, 13C NMR and mass spectroscopy and subjected to screening against chloroquine sensitive RKL2 strain of Plasmodium falciparum in 96 well-microtitre plates. However, synthesized derivatives exhibit mild to moderate antimalarial activity and acute toxicity studies of the most active (6a and 6g) compounds were shown to have no significant change in body insight and toxic sign.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S625-S631
نویسندگان
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