کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5142544 1496034 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antimalarial activity evaluation of 3-(3-(7-chloroquinolin-4-ylamino)propyl)-1,3-thiazinan-4-one derivatives
ترجمه فارسی عنوان
بررسی سنتز و فعالیت های ضد مالاریایی مشتقات 3- (3- (7-کلروکینولین-4-یلامینو) پروپیل) -1،3-تیزینین-4-یک
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی
Some novel derivatives of 3-(3-(7-chloroquinolin-4-ylamino)propyl)-1,3-thiazinan-4-one were synthesized and characterized by their physical and spectral data. All the synthesized compounds were subsequently screened for in vitro antimalarial activity against chloroquine sensitive strain of Plasmodium falciparum (RKL-2) employing chloroquine as the reference drug. Most of the synthesized compounds exhibited mild to moderate susceptibilities towards the parasite in comparison to the standard. It was found that antimalarial activity of 3-(3-(7-chloroquinolin-4-ylamino)propyl)-2-(4-bromophenyl)-1,3-thiazinan-4-one was marginally superior than all the compounds evaluated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S643-S647
نویسندگان
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