کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
514334 866729 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stabilized space–time finite elements for high-definition simulation of packed bed chromatography
ترجمه فارسی عنوان
عناصر محدود به فضا ثابت شده برای شبیه سازی بالا تعریف کروماتوگرافی تخت بسته بندی شده
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
چکیده انگلیسی


• A space–time finite element method has been tailored to multidomain mass transfer problems.
• Packed bed chromatography is simulated in full spatial resolution.
• Different binding models and boundary conditions are implemented.
• The solver is parallelized to solve realistic problems on high performance computers.

We present a finite element scheme for spatially resolved simulations of fluid flow and mass transfer in chromatography columns. Packed bed chromatography is an important unit operation for the purification of product molecules in biopharmaceutical industry. The problem combines different challenges arising from advection dominance, stiffness due to the presence of reaction terms, and from the size of the resulting linear equation systems. We show that our stabilized space–time finite element method can handle these difficulties adequately and solve test problems efficiently.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Finite Elements in Analysis and Design - Volume 86, 1 September 2014, Pages 1–11
نویسندگان
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