Cytotoxic organometallic [Ru(η6-anethole)(en)(X)]PF6 (X = Br or I) complexes: Synthesis, characterization and in vitro biological evaluation

Two new organometallic compounds were synthesized in this study, namely, [Ru(η6-anethole)(en)(X)]PF6, where X = Br (5) or I (6), in order to assess the effect of different leaving groups on the biological activity of the Ru(η6-anethole)(en) scaffold. Compound 6 exhibited some selectivity (3-fold) between the human colon tumor (HT-29) and human colon non-tumor (CCD-841) cell lines that make this compound suitable for further drug development studies.109