A porous Ca-MOF with nano-sized {Ca11} as building unit: Structure, drug loading and release properties

A novel calcium based metal-organic framework (compound 1) was assembled from the connection of nano-sized {Ca11}SBU (2.36nm) and the triple-connective triangle aromatic acid, to give the formation of 3D MOF of 1 companied with a 2D porous structure with two 1D channel (size: 10.7Å × 10.8Å and 9.4Å × 8.1Å, respectively). The framework of 1 can afford a drug loading content of 0.19g/g of guaiacol and exhibited slow release effect toward guaiacol in 15h in PBS solution.268