Discovery of novel diarylpyrazolylquinoline derivatives as potent anti-dengue virus agents

New diarylpyrazolylquinolines with anti-DENV activity were designed and synthesized. Among them, compound 13c was potent inhibited all four sero-types of DENV. It can effectively protect mice from DENV infection by reducing disease symptoms and mortality of DENV-infected mice.128