Synthesis, structure-activity relationships and preliminary mechanism of action of novel water-soluble 4-quinolone-3-carboxamides as antiproliferative agents

A series of novel water-soluble 4-quinolone-3-carboxamides was prepared and evaluated as antitumor agents. The representative compound 8k could trigger p53/Bax-independent colorectal cancer cell apoptosis via inducing ROS accumulation.157