کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5158467 | 1501077 | 2017 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies](/preview/png/5158467.png)
چکیده انگلیسی
A series of 1, 2,3-triazoles derivatives were synthesized at the C-7Ⲡposition of the gomisin B core through click protocol. Among them, cell cycle analysis indicated that compound 5b caused a cell cycle arrest of HeLa cells at G2/M phase and also promoted tubulin polymerization, similar to Paclitaxel. Overall, we identified a novel small molecule that demonstrated anticancer activity by promoting in vivo tubulin assembly.212
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 139, 20 October 2017, Pages 441-453
Journal: European Journal of Medicinal Chemistry - Volume 139, 20 October 2017, Pages 441-453
نویسندگان
B. Poornima, Bandi Siva, A. Venkanna, G. Shankaraiah, Nishant Jain, Dharmendra Kumar Yadav, Sanjeev Misra, K. Suresh Babu,