Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action

In this study, forty-four chiral triazole derivatives have been synthesized via asymmetric synthesis, and their in vitro antiviral activities against EV71 and CVB3 were fully investigated in cell-based assays, and the results indicated the most potential molecules are the compounds 10 and 43 with S-configuration, and which exhibit good TI values compared with the control Ribavirin.518