Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

Aiming to develop potent agonist with improved efficacy and safety, we have identified series of FFA1 agonists bearing sulfone-carboxylic acid moiety, exemplified by the potent and orally bioavailable agonist 20.322