Design, synthesis and 2D QSAR study of novel pyridine and quinolone hydrazone derivatives as potential antimicrobial and antitubercular agents

Compounds 6o, 6p, and 6r displayed superior antimycobacterial (MIC = 0.39 μg/mL) and antimicrobial (MICs = 0.49-3.9 μg/mL) activities. Compounds 6e, 6f, 6l and 6n showed very good antimycobacterial activities with MIC 0.78 μg/mL and good antimicrobial activity MICs = 0.49-15.63 μg/mL.176