کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
518261 867571 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein annotation from protein interaction networks and Gene Ontology
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
Protein annotation from protein interaction networks and Gene Ontology
چکیده انگلیسی

We introduce a novel method for annotating protein function that combines Naïve Bayes and association rules, and takes advantage of the underlying topology in protein interaction networks and the structure of graphs in the Gene Ontology. We apply our method to proteins from the Human Protein Reference Database (HPRD) and show that, in comparison with other approaches, it predicts protein functions with significantly higher recall with no loss of precision. Specifically, it achieves 51% precision and 60% recall versus 45% and 26% for Majority and 24% and 61% for χ2-statistics, respectively.


► We introduce a novel method for annotating protein function that combines Naïve Bayes and association rules.
► We explore the underlying topology in protein interaction networks and the structure of graphs in the Gene Ontology.
► Our model achieves 51% precision and 60% recall on HPRD database.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomedical Informatics - Volume 44, Issue 5, October 2011, Pages 824–829
نویسندگان
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