کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
522300 867822 2007 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diffusion on a curved surface coupled to diffusion in the volume: Application to cell biology
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
Diffusion on a curved surface coupled to diffusion in the volume: Application to cell biology
چکیده انگلیسی

An algorithm is presented for solving a diffusion equation on a curved surface coupled to diffusion in the volume, a problem often arising in cell biology. It applies to pixilated surfaces obtained from experimental images and performs at low computational cost. In the method, the Laplace–Beltrami operator is approximated locally by the Laplacian on the tangential plane and then a finite volume discretization scheme based on a Voronoi decomposition is applied. Convergence studies show that mass conservation built in the discretization scheme and cancellation of sampling error ensure convergence of the solution in space with an order between 1 and 2. The method is applied to a cell-biological problem where a signaling molecule, G-protein Rac, cycles between the cytoplasm and cell membrane thus coupling its diffusion in the membrane to that in the cell interior. Simulations on realistic cell geometry are performed to validate, and determine the accuracy of, a recently proposed simplified quantitative analysis of fluorescence loss in photobleaching. The method is implemented within the Virtual Cell computational framework freely accessible at www.vcell.org.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Computational Physics - Volume 226, Issue 2, 1 October 2007, Pages 1271–1290
نویسندگان
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