کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5490915 1524783 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adaptable setups for magnetic drug targeting in human muscular arteries: Design and implementation
ترجمه فارسی عنوان
تنظیمات قابل تنظیم برای مواد مغذی هدفمند در شریان های عضلانی انسان: طراحی و پیاده سازی
کلمات کلیدی
هدفگیری مغناطیسی، تحویل مواد مخدر، عضلانی ردیابی ذرات، اعتبار درون آزمایشگاهی،
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی
Magnetic drug targeting has been used to steer magnetic therapeutic agents and has received much attention for capillaries and human brain arteries. In this paper, we focus on noninvasive targeting of nanoparticles in muscular arteries, in where the vessel diameter and blood flow are much challengingly higher than brain capillaries. We aim to design a low intensity magnetic field which avoids potential side effects on blood cells while steers particles with high targeting rate. The setup design procedure is considerably flexible to be used in a wide variety of large vessels. Using particle tracing, a new method is proposed to connect the geometry of the vessel under the action of targeting to the required magnetic force. Specifications of the coil which is placed outside the body are derived based on this required force. Mutual effects of coil dimensions on the produced magnetic force are elaborated and summarized in a design flowchart to be used for arbitrary muscular vessel sizes. The performance of the optimized coil is validated by in vitro experiments and it is shown that particles are steered with the average efficiency of 80.2% for various conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 438, 15 September 2017, Pages 173-180
نویسندگان
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