کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5491176 1524794 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and characterization of a device to quantify the magnetic drug targeting efficiency of magnetic nanoparticles in a tube flow phantom by magnetic particle spectroscopy
ترجمه فارسی عنوان
طراحی و مشخص کردن یک وسیله برای اندازه گیری راندمان مغناطیسی هدفمند سازی نانو ذرات مغناطیسی در یک فانتوم جریان لوله توسط طیف سنجی ذرات مغناطیسی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی
The aim of magnetic drug targeting (MDT) is to transfer a therapeutic drug coupled to magnetic nanoparticles (MNP) to desired disease locations (e.g. tumor region) with the help of magnetic field gradients. To transfer the MDT approach into clinical practice a number of important issues remain to be solved. We developed and characterized an in-vitro flow phantom to provide a defined and reproducible MDT environment. The tube system of the flow phantom is directed through the detection coil of a magnetic particle spectroscopy (MPS) device to determine the targeting efficiency. MPS offers an excellent temporal resolution of seconds and an outstanding specific sensitivity of some nanograms of iron. In the flow phantom different MNP types, magnet geometries and tube materials can be employed to vary physical parameters like diameter, flow rate, magnetic targeting gradient, and MNP properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 427, 1 April 2017, Pages 175-180
نویسندگان
, , , ,