کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5491177 1524794 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studies of aggregated nanoparticles steering during magnetic-guided drug delivery in the blood vessels
ترجمه فارسی عنوان
مطالعات فرمان نانوذرات جمع شده در هنگام تحویل داروی مواد مغناطیسی در رگ های خونی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی
Magnetic-guided targeted drug delivery (TDD) systems can enhance the treatment of diverse diseases. Despite the potential and promising results of nanoparticles, aggregation prevents precise particle guidance in the vasculature. In this study, we developed a simulation platform to investigate aggregation during steering of nanoparticles using a magnetic field function. The magnetic field function (MFF) comprises a positive and negative pulsed magnetic field generated by electromagnetic coils, which prevents adherence of particles to the vessel wall during magnetic guidance. A commonly used Y-shaped vessel was simulated and the performance of the MFF analyzed; the experimental data were in agreement with the simulation results. Moreover, the effects of various parameters on magnetic guidance were evaluated and the most influential identified. The simulation results presented herein will facilitate more precise guidance of nanoparticles in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 427, 1 April 2017, Pages 181-187
نویسندگان
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