کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5491182 | 1524794 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field
ترجمه فارسی عنوان
هیدروژل مغناطیسی مقاوم در برابر حرارت پویا و زیست سازگار است که به میدان مغناطیسی متناوب پاسخ می دهد
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کلمات کلیدی
هیدروژل مغناطیسی، نانوذرات مغناطیسی، هیپرترمی، زیر بغل پاسخگو، مکانیکولوژی،
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
چکیده انگلیسی
Magnetic thermo-responsive hydrogels are a new class of materials that have recently attracted interest in biomedicine due to their ability to change phase upon magnetic stimulation. They have been used for drug release, magnetic hyperthermia treatment, and can potentially be engineered as stimuli-responsive substrates for cell mechanobiology. In this regard, we propose a series of magnetic thermo-responsive nanocomposite substrates that undergo cyclical swelling and de-swelling phases when actuated by an alternating magnetic field in aqueous environment. The synthetized substrates are obtained with a facile and reproducible method from poly-N-isopropylacrylamide and superparamagnetic iron oxide nanoparticles. Their conformation and the temperature-related, magnetic, and biological behaviors were characterized via scanning electron microscopy, swelling ratio analysis, vibrating sample magnetometry, alternating magnetic field stimulation and indirect viability assays. The nanocomposites showed no cytotoxicity with fibroblast cells, and exhibited swelling/de-swelling behavior near physiological temperatures (around 34 °C). Therefore these magnetic thermo-responsive hydrogels are promising materials as stimuli-responsive substrates allowing the study of cell-behavior by changing the hydrogel properties in situ.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 427, 1 April 2017, Pages 212-219
Journal: Journal of Magnetism and Magnetic Materials - Volume 427, 1 April 2017, Pages 212-219
نویسندگان
Federica Crippa, Thomas L. Moore, Mariangela Mortato, Christoph Geers, Laetitia Haeni, Ann M. Hirt, Barbara Rothen-Rutishauser, Alke Petri-Fink,