کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5491204 | 1524794 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of a real time imaging-based guidance system of magnetic nanoparticles for targeted drug delivery
ترجمه فارسی عنوان
توسعه یک سیستم هدایت مبتنی بر تصویربرداری واقعی از نانوذرات مغناطیسی برای تحویل دارو هدفمند
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کلمات کلیدی
تصویربرداری ذرات مغناطیسی، نانوذرات، محرک الکترومغناطیسی، سیستم هدایت، تحویل دارو هدفمند،
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
چکیده انگلیسی
Targeted drug delivery using magnetic nanoparticles is an efficient technique as molecules can be directed toward specific tissues inside a human body. For the first time, we implemented a real-time imaging-based guidance system of nanoparticles using untethered electro-magnetic devices for simultaneous guiding and tracking. In this paper a low-amplitude-excitation-field magnetic particle imaging (MPI) is introduced. Based on this imaging technology, a hybrid system comprised of an electromagnetic actuator and MPI was used to navigate nanoparticles in a non-invasive way. The real-time low-amplitude-excitation-field MPI and electromagnetic actuator of this navigation system are achieved by applying a time-division multiplexing scheme to the coil topology. A one dimensional nanoparticle navigation system was built to demonstrate the feasibility of the proposed approach and it could achieve a 2Â Hz navigation update rate with the field gradient of 3.5Â T/m during the imaging mode and 8.75Â T/m during the actuation mode. Particles with both 90Â nm and 5Â nm diameters could be successfully manipulated and monitored in a tube through the proposed system, which can significantly enhance targeting efficiency and allow precise analysis in a real drug delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 427, 1 April 2017, Pages 345-351
Journal: Journal of Magnetism and Magnetic Materials - Volume 427, 1 April 2017, Pages 345-351
نویسندگان
Xingming Zhang, Tuan-Anh Le, Jungwon Yoon,