کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5502585 | 1535082 | 2017 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
The Framingham Stroke Risk Profile (FSRP) is a novel and reliable tool for estimating the 10-year probability for incident stroke in stroke-free individuals, while the predictive value of ambulatory blood pressure monitoring (ABPM) for first-ever and recurrent stroke has been well established. We sought to evaluate cross-sectionally the association of ABPM parameters with FSRP score in a large sample of 2343 consecutive stroke-free individuals (mean age: 56.0 ± 12.9, 49.1% male) who underwent 24-hour ABPM. True hypertensives showed significantly higher FSRP (11.2 ± 5.0) compared to the normotensives (8.2 ± 5.0, p < 0.001), while subjects with white coat hypertension also had higher FSRP (10.2 ± 4.7) than normotensives (8.2 ± 5.0, p < 0.001). Compared to dippers that exhibited the lowest FSRP, non-dippers and reverse-dippers exhibited significantly higher FSRP (9.8 ± 4.8 for dippers vs 10.6 ± 5.2 and 11.5 ± 5.0 for non-dippers and reverse-dippers respectively, p â¤Â 0.001 for comparisons). In univariate analyses, the ABPM parameters that had the strongest correlation with FSRP were 24-hour (r = 0.440, p < 0.001), daytime (r = 0.435, p < 0.001) and night-time (r = 0.423; p < 0.001) pulse pressure (PP). The best fitting model for predicting FSRP (R2 = 24.6%) on multiple linear regression analyses after adjustment for vascular risk factors not included in FSRP comprised the following parameters in descending order: 24-hour PP (β = 0.349, p < 0.001), daytime SBP variability (β = 0.124, p < 0.001), 24-hour HR variability (β = â 0.091, p < 0.001), mean 24-hour HR (β = â 0.107, p < 0.001), BMI (β = 0.081, p < 0.001) and dipping percentage (β = â 0.063, p = 0.001). 24-hour PP and daytime SBP variability are the two ABPM parameters that were more strongly associated with FSRP-score. Reverse dippers had the highest FSRP among all dipping status profiles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 380, 15 September 2017, Pages 106-111
Journal: Journal of the Neurological Sciences - Volume 380, 15 September 2017, Pages 106-111
نویسندگان
Georgios Tsivgoulis, Maria Pikilidou, Aristeidis H. Katsanos, Kimon Stamatelopoulos, Fotios Michas, Aikaterini Lykka, Christina Zompola, Angeliki Filippatou, Efstathios Boviatsis, Konstantinos Voumvourakis, Nikolaos Zakopoulos, Efstathios Manios,