کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5502647 | 1535085 | 2017 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
18F-fallypride PET-CT of dopamine D2/D3 receptors in patients with sporadic amyotrophic lateral sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with unclear pathogenesis. To date, there have been no reports regarding the distribution of dopamine receptors outside the striatum in ALS patients. In this study, 17 ALS patients and 11 healthy controls underwent 18F-fallypride positron emission tomography/computed tomography (PET/CT) and completed cognitive-related tests for assessment of the distribution of dopamine receptors inside and outside the striatum in ALS and evaluation of the relationships between the distribution of dopamine receptors and cognitive function. The results showed that ALS patients showed significantly lower scores only in language and delayed recall of Montreal Cognitive Assessment scale. There were no significant differences between the two groups in the cognitive-related test results. Statistical parametric mapping (SPM) data showed that the binding affinity of 18F-fallypride in ALS patients was decreased in the bilateral nucleus accumbens septi, bilateral frontal lobes, and the superior frontal gyrus, left temporal lobe, and angular gyrus regions. In conclusion, the levels of dopamine receptors were significantly decreased in some areas outside the striatum in patients with ALS, which may contribute to mild cognitive impairment in ALS patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 377, 15 June 2017, Pages 79-84
Journal: Journal of the Neurological Sciences - Volume 377, 15 June 2017, Pages 79-84
نویسندگان
Xiaoling Fu, Wenjia Zhu, Zhe Guo, Gangming Shu, Fang Cui, Fei Yang, Ying Zhang, Yuting Ren, Xiaojun Zhang, Xiaolan Zhang, Zhaohui Chen, Li Ling, Xusheng Huang, Jinming Zhang,