کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5502729 | 1535083 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations between white matter hyperintensities and cognitive decline over three years in non-dementia older adults with memory complaints
ترجمه فارسی عنوان
ارتباط بین شدت بی حسی ماده سفید و کاهش شناختی بیش از سه سال در افراد مسن غیر دمانسی که شکایت حافظه دارند
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کلمات کلیدی
شناخت، کمبود شدید ماده سفید، طولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
We investigated whether the baseline level and overtime changes of white matter hyperintensities (WMH) would be associated with cognitive decline over three years in non-demented older adults with memory complaints. 109 participants with baseline magnetic resonance imaging (MRI) and follow-up cognitive assessments up to 3-year were included; among them, 82 also had a follow-up MRI assessment over three years. WMH volume was obtained by an automated segmentation algorithm. Baseline WMH volumes and change between baseline and follow-up WMH were related to cognitive scores over time using mixed-effect linear regressions. Secondary stratified analyses according to Clinical Dementia Rating (CDR) status, APOE4 status, and presence of amyloid in the brain were conducted using similar regression models. Change in WMH volume overtime was associated with declines in COWAT (β = â 0.239; 95% CI = â 0.381, â 0.096, p = 0.001). Baseline WMH was not associated to any of the cognitive tests. Secondary analysis found that baseline WMH was associated to declines in TMT-A in APOE4 non-carriers (β = 0.343; 95% CI = 0.121, 0.564, p = 0.003) and CDR 0 groups (β = 0.307; 95% CI = 0.095, 0.519, p = 0.005); in CDR 0 group, overtime changes in WMH was associated to declines on both TMT-A (β = 0.698; 95% CI = 0.270, 1.126, p = 0.002) and TMT-B (β = 2.573; 95% CI = 1.200, 3.947, p < 0.001). Changes in WMH volume are associated with declines in information processing speed and executive function in non-demented older adults with memory complaints. Overtime changes in WMH volume is probably a better determinant of cognitive function in the elderly than baseline WMH volume.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 379, 15 August 2017, Pages 266-270
Journal: Journal of the Neurological Sciences - Volume 379, 15 August 2017, Pages 266-270
نویسندگان
So Young Moon, Philipe de Souto Barreto, Marie Chupin, Jean François Mangin, Ali Bouyahia, Ludovic Fillon, Sandrine Andrieu, Bruno Vellas, for the MAPT/DSA group for the MAPT/DSA group,