کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5502848 | 1535084 | 2017 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Improved strength on 5-hydroxytryptophan and carbidopa in spinal cord atrophy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Improved strength on 5-hydroxytryptophan and carbidopa in spinal cord atrophy Improved strength on 5-hydroxytryptophan and carbidopa in spinal cord atrophy](/preview/png/5502848.png)
چکیده انگلیسی
There is ample evidence of an important role of descending serotonergic projections in modulating spinal motor neuron activation and firing, and experimental studies suggest that 5-HT receptor stimulation can improve motor function after spinal cord injury; however, relevant clinical data is sorely lacking. We describe two sisters with hemiplegic migraine, low CSF and platelet serotonin levels, and progressive spastic paraparesis associated with profound spinal cord atrophy whose lower extremity strength and ambulation responded to a precursor replacement strategy (5-hydroxytryptophan and carbidopa administration), an approach that may have broader applicability in myelopathies of diverse etiology where descending serotonergic projections are compromised.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 378, 15 July 2017, Pages 59-62
Journal: Journal of the Neurological Sciences - Volume 378, 15 July 2017, Pages 59-62
نویسندگان
Gabriella A. Horvath, Lorelyn Meisner, Kathryn Selby, Robert Stowe, Bruce Carleton,