کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5503046 1535089 2017 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disease progression and oxidative stress are associated with higher serum ferritin levels in patients with multiple sclerosis
ترجمه فارسی عنوان
پیشرفت بیماری و استرس اکسیداتیو با افزایش سطح فریتین سرم در بیماران مبتلا به مولتیپل اسکلروزیس همراه است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Hyperferritinemia and oxidative stress have been implicated in the pathogenesis of multiple sclerosis (MS). The aim of the present study was to evaluate the serum levels of ferritin and to verify their association with oxidative stress markers and MS progression. This study included 164 MS patients, which were divided in two groups according to their levels of ferritin (cut off 125.6 μg/L). Oxidative stress was evaluated by tert-butyl hydroperoxide-initiated chemiluminescence (CL-LOOH), advanced oxidation protein products (AOPP), carbonyl protein, nitric oxide metabolites (NOx), sulfhydryl groups of protein and total radical-trapping antioxidant parameter (TRAP). MS patients with elevated levels of ferritin showed higher disease progression (p = 0.030), AOPP (p = 0.001), and lower plasma NOx levels (p = 0.031) and TRAP (p = 0.006) than MS patients with lower ferritin levels. The multivariate binary logistic regression analysis showed that increased AOPP and progression of disease were significantly and positively associated with increase of ferritin. The combination of serum ferritin levels and oxidative stress markers were responsible for 13,9% in the disease progression. In conclusion, our results suggest that ferritin could aggravate oxidative stress in patients with MS and contribute to progression of disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 373, 15 February 2017, Pages 236-241
نویسندگان
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