کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5504002 1535816 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson's disease
ترجمه فارسی عنوان
اتصال تابعی تغییر یافته در شبکه حالت پیش فرض همراه با نقص شناختی و تغییرات تشریحی مغز در بیماری پارکینسون
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


- Default mode network (DMN) functional connectivity disruption is present in PD.
- DMN disruption is related to gray and white matter abnormalities in PD.
- DMN alteration is related to memory and visual cognitive impairment in PD.

ObjectiveTo assess whether functional neural connectivity is disrupted between the regions of the default mode network (DMN) in Parkinson's disease (PD) and how this connectivity is related to cognition, brain gray matter structure and white matter integrity and diffusivity.MethodsThirty-seven PD patients and 16 healthy controls were evaluated, using resting-state functional magnetic resonance imaging (MRI), T1-weighted MRI, diffusion-weighted imaging and a battery of cognitive tests. Functional connectivity between the regions of the DMN, specifically in the precuneus, anterior and posterior cingulate, medial prefrontal and temporal and inferior parietal cortices was assessed with seed-to-voxel connectivity; gray matter volume and white matter values were determined using voxel-based morphometry and tract-based spatial statistics.ResultsReduced functional connectivity was observed between the posterior cingulate and medial temporal lobe in PD. Lower cognitive performance, gray matter loss in posterior, medial temporal and parietal areas, and fractional anisotropy reduction in the white matter adjacent to DMN regions were also observed in PD patients compared with healthy controls. Lower DMN functional connectivity correlated with lower verbal and visual memory and visual abilities performance in PD. In addition, lower DMN functional connectivity correlated with lower gray matter volume in the posterior cingulate and precuneus, and with lower white matter fractional anisotropy of the inferior longitudinal and posterior cingulate fasciculi in PD.ConclusionsBy combining different neuroimaging techniques and cognitive data, results showed that functional connectivity alteration between the regions of the DMN is associated with lower cognitive performance and gray and white matter abnormalities in PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 33, December 2016, Pages 58-64
نویسندگان
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