کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5504130 | 1400215 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The impact of black seed oil on tramadol-induced hepatotoxicity: Immunohistochemical and ultrastructural study
ترجمه فارسی عنوان
تاثیر روغن دانه سیاه دانه بر سمیت گوارشی ناشی از ترامادول: مطالعه ایمونوهیستوشیمی و فراوانی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The natural herb, black seed (Nigella Sativa; NS) is one of the most important elements of folk medicine. The aim was to evaluate the impact of Nigella Sativa Oil (NSO) on the changes induced by tramadol in rat liver. Twenty four albino rats were used. Control group: given intraperitoneal and oral saline for 30Â days. TR-group: given intraperitoneal tramadol (20, 40, 80Â mg/kg/day) in the first, middle and last 10Â days of the experiment, respectively. TRÂ +Â NS group: administered intraperitoneal tramadol in similar doses to TR-group plus oral NSO (4Â ml/kg/day) for 30Â days. Immunohistochemical, electron microscopic, biochemical and statistical studies were performed. TR-group displayed disarranged hepatic architecture, hepatic congestion, hemorrhage and necrosis. Apoptotic hepatocytes, mononuclear cellular infiltration and a significant increase in the number of anti-CD68 positive cells were observed. Ultrastructurally, hepatocytes showed shrunken nuclei, swollen mitochondria, many lysosomes and autophagic vacuoles. Activated Ito and Von Kupffer cells were also demonstrated. Elevated serum levels of AST, ALT, ALP and bilirubin were noticed. NSO administration resulted in preservation of hepatic histoarchitecture and ultrastructure and significant reductions in the number of anti-CD68 positive cells and serum levels of liver seromarkers. In conclusion, NSO administration could mitigate the alterations induced by tramadol in rat liver.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 119, Issue 5, June 2017, Pages 543-554
Journal: Acta Histochemica - Volume 119, Issue 5, June 2017, Pages 543-554
نویسندگان
Nesreen Moustafa Omar, Mohammed Amin Mohammed,