کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5507099 1536899 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Specific titin and myomesin domains stimulate myoblast proliferation
ترجمه فارسی عنوان
دامنه اختصاصی تیتین و میکومیسین، تکثیر مایوبلاست را تحریک می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- Titin and myomesin as well as their domains stimulate myoblast proliferation.
- Ig-like and Fn type III domains activate proliferation via different pathways.
- IGF-1 autocrine signalling is partially involved in observed proliferative effects.

Myofibrillar proteins titin and myomesin stimulated myoblast proliferation as determined by MTT-test and labelled thymidine incorporation in the DNA. Specific Fn type III and Ig-like domains of these proteins were able to exert mitogenic effects as well. Proliferative effect of Fn type III domains was highly sensitive to inhibition of Ca2+/calmodulin dependent protein kinase, whereas the effect of Ig-like domains showed greater sensitivity to the inhibition of adenylyl cyclase - cAMP - PKA pathway. IGF-1 autocrine signalling inhibition partially suppressed mitogenic effects revealed by both domain types.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemistry and Biophysics Reports - Volume 9, March 2017, Pages 226-231
نویسندگان
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