کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5517774 | 1543678 | 2016 | 6 صفحه PDF | دانلود رایگان |
Aim of this study was to determine the incidence and molecular epidemiology of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in Germany. E. coli and K. pneumoniae isolates from clinical samples which were non-susceptible to carbapenems were collected in laboratories serving 20 hospitals throughout Germany from November 2013 to April 2014. The isolates were tested for the presence of carbapenemases by PCR and phenotypic methods and typed by multilocus sequence typing. Risk factors including a previous hospitalization abroad were analysed. Carbapenemases were detected in 24 isolates from 22 patients out of 464,514 admissions. Carbapenemases included OXAâ48 (n = 14), KPCâ2 (n = 8) and NDMâ1 (n = 2). Except for two K. pneumoniae isolates with ST101, all OXAâ48 producing strains belonged to different clones. In contrast, half of KPCâ2 producing K. pneumoniae were of ST258 and both NDMâ1 producing strains were of ST11. Compared to carbapenem-susceptible controls, patients with carbapenemase-producing strains differed by a significantly higher proportion of males, a higher proportion of isolates from wound samples and a more frequent previous stay abroad in univariate analysis. This multicentre study demonstrated an incidence of carbapenemase-producing E. coli and K. pneumoniae from clinical samples in Germany of 0.047 cases per 1000 admissions. OXAâ48 was more frequent than KPCâ2 and NDMâ1 and showed a multiclonal background.
Journal: International Journal of Medical Microbiology - Volume 306, Issue 6, September 2016, Pages 415-420