کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5517829 1543679 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mini reviewFaecal microbiota transplantation-A clinical view
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Mini reviewFaecal microbiota transplantation-A clinical view
چکیده انگلیسی


- Faecal microbiota transplantation is curative for Clostridium difficile infection.
- The intestinal microbiota in inflammatory bowel disease has a reduced diversity.
- Obesity indicates the feasibility of transferring a phenotype from a donor to a recipient.

Faecal microbiota transplantation has gained increasing attention over the last decade as various phenotypes could be transferred from a donor to a recipient in different animal models. Clinically, however, the sole indication with evidence from a randomized placebo controlled trial is refractory Clostridium difficile infection. Despite revealing successful clinical outcomes, questions concerning regulatory affairs, the identification of the best donor, the optimal mixture of the transplant as well as the preferred route of administration remain to be clarified even for this indication. Initiated by the idea that alterations in the composition of the intestinal microbiota are associated with intestinal inflammation in inflammatory bowel disease, several studies investigated whether faecal microbiota transplantation would be an equally suitable approach for these devastating disorders. Indeed, the available data indicate changes in the microbiota composition following faecal microbial transplantation depending on the degree of intestinal inflammation. Furthermore, first data even provide evidence that the transplantation of an “optimized” microbiota induces clinical remission in ulcerative colitis. However, despite these intriguing results it needs to be considered that not only “a cure of inflammation”, but also risk factors and phenotypes including obesity can be transferred via faecal microbiota transplantation. Thus, a deeper understanding of the impact of a distinct microbiota composition is required before “designing” the optimal faecal microbiota transplant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Medical Microbiology - Volume 306, Issue 5, August 2016, Pages 310-315
نویسندگان
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